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Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease
characterized by inflammation and joint structural deterioration. Driven by recent
expectations that patients in clinical trials randomized to placebo should be
'rescued' with active therapy within 6 months of starting treatment, the relative
benefit of arresting joint ... read moredamage with biologic agents beyond this period is unclear.
With longer-term evidence of the rate of joint deterioration with minimal treatment,
the efficacy of biologic agents and novel treatments might be projected beyond the
placebo-controlled phase observed in clinical trials. The aim of this study was to
estimate radiographic structural deterioration over time in patients with
moderate-to-severe RA minimally treated with DMARDs.
Keywords: Joint erosions, Longitudinal studies, Meta-analysis,
Radiography, Rheumatoid arthritis.
Springer Open.read less
- Jansen, Jeroen, Maria-Cecilia Vieira, John D. Bradley, Joseph
C. Cappelleri, Samuel H. Zwillich, and Gene V. Wallenstein. "Meta-analysis of
long-term joint structural deterioration in minimally treated patients with
rheumatoid arthritis." BMC Musculoskeletal Disorders 17, no. 1 (12, 2016):