%0 PDF %T Meta-analysis of long-term joint structural deterioration in minimally treated patients with rheumatoid arthritis. %A Jansen, Jeroen P.; Vieira, Maria-Cecilia.; Bradley, John D.; Cappelleri, Joseph C.; Zwillich, Samuel H.; Wallenstein, Gene V. %D 2016-08-22T12:23:26.537Z %8 2016-08-22 %R http://localhost/files/xp68kt77j %X Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint structural deterioration. Driven by recent expectations that patients in clinical trials randomized to placebo should be 'rescued' with active therapy within 6 months of starting treatment, the relative benefit of arresting joint damage with biologic agents beyond this period is unclear. With longer-term evidence of the rate of joint deterioration with minimal treatment, the efficacy of biologic agents and novel treatments might be projected beyond the placebo-controlled phase observed in clinical trials. The aim of this study was to estimate radiographic structural deterioration over time in patients with moderate-to-severe RA minimally treated with DMARDs.; Keywords: Joint erosions, Longitudinal studies, Meta-analysis, Radiography, Rheumatoid arthritis.; Springer Open. %[ 2018-10-11 %9 Text %~ Tufts Digital Library %W Institution