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Near-infrared spectroscopy (NIRS), in combination with coherent hemodynamics
spectroscopy (CHS), provides information about the cerebral microvasculature in terms of
cerebral blood flow, cerebral blood volume, and the cerebral metabolic rate of oxygen.
We characterize the frequency-dependent relationship between tissue concentrations of
oxyhemoglobin and deoxyhemoglobin, measured ... read morewith NIRS, as well as the relationship
between total hemoglobin concentration and arterial blood pressure in healthy subjects.
We use the hemodynamic model of CHS for the analysis of the results to yield physiologic
parameters such as absolute cerebral blood flow and cerebral autoregulation. Further, we
demonstrate the application of NIRS-CHS in the clinical setting of the neurocritical
Thesis (Ph.D.)--Tufts University,
Submitted to the Dept. of Biomedical
Committee: Irene Georgakoudi, Brian Tracey,
and Joshua Kornbluth.