Background: The size of the vertebrate eye and the retina is likely to
be controlled at several stages of embryogenesis by mechanisms that affect cell cycle
length as well as cell survival. A mutation in the zebrafish out of sight (out) locus
results in a particularly severe reduction of eye size. The goal of this study is to
characterize... read morethe out m233mutant, and to determine whether mutations in the out gene
cause microphthalmia in humans.
den Hollander, Anneke, Janisha Biyanwila, Peter Kovach, Tanya
Bardakjian, Elias I. Traboulsi, Nicola K. Ragge, Adele Schneider, and Jarema Malicki.
"Genetic defects of GDF6 in the zebrafish out of sight mutant and in human eye
developmental anomalies." BMC Genetics 11, no. 1 (12, 2010):