Detecting Between-Pathway Model conservation across S. cerevisiae and S. pombe yeast species.

Malmer, Daniel A.


  • The Between-Pathway Model (BPM) motif identifies pairs of fault-tolerant gene pathways within the yeast interactome. In BPMs, many gene pairs between the two pathways contain synthetic lethal interactions, meaning if you knock out one gene or the other only, the yeast lives, while knocking out both is lethal. This suggests that each pathway in a BPM compensates when an opposite pathway is suppress... read more
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