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Abstract: Determining
whether the peritoneum is positive for metastases is an important factor when a
clinician stages the progression of various abdominal cancers. Currently, the
examination of the peritoneum takes place via laparoscopy, however the sensitivity with
which cancer lesions are detected with this method needs improvement. This work is
concerned with the application of differentially ... read morepolarized light (DPL) imaging in
laparoscopy to improve the contrast of surface features resembling cancer lesions. The
performance of this imaging modality was assessed through examination of tissue phantoms
and ex vivo samples modeling the optical properties of the metastatic peritoneum. It was
found that compared to current conventional imaging, DPL imaging substantially increases
the contrast of tumor tissue on a peritoneal surface in a human biopsy sample. With
this, an optical system was also designed to enable DPL imaging in a clinical
laparoscope.
Thesis (M.S.)--Tufts University,
2017.
Submitted to the Dept. of Biomedical
Engineering.
Advisor: Irene
Georgakoudi.
Committee: Irene Georgakoudi, Thomas
Schnelldorfer, and Xiaocheng Jiang.
Keywords:
Biomedical engineering, and Medical
imaging.read less
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