Intrinsic-fluorescence markers reveal high-risk HPV infection and cervical precancer.

MacDonald, Douglas.


  • Abstract: Reliable optical markers are key to timely detection of cervical precancer caused by high-risk strains of human papillomavirus (HPV). Using a murine model, we acquired time-lapse epifluorescence images of intrinsic NADH and FAD fluorescence in monolayer cultures of dermal fibroblasts with and without the HPV-16 E7 gene. We measured the resulting image sequences with 38 different spatio­t... read more
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