| Description |
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Background: The fungal pathogen Candida albicans colonizes the
gastrointestinal (GI) tract of mammalian hosts as a benign commensal. However, in an
immunocompromised host, the fungus is capable of causing life-threatening infection.
We previously showed that the major transcription factor Efg1p is differentially
expressed in GI-colonizing ... read moreC. albicans cells dependent on the host immune status. To
understand the mechanisms that underlie this host-dependent differential gene
expression, we utilized mathematical modeling to dissect host-pathogen interactions.
Specifically, we used principles of evolutionary game theory to study the mechanism
that governs dynamics of EFG1 expression during C. albicans
colonization.
Keywords: Candida albicans, Colonization, Fungal pathogen, Microbiota,
Efg1p, Evolutionary game theory, Mathematical modeling.
Springer Open.read less
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| Citation |
- Tyc, Katarzyna, Sanna E. Herwald, Jennifer A. Hogan, Jessica
V. Pierce, Edda Klipp, and Carol A. Kumamoto. "The game theory of Candida albicans
colonization dynamics reveals host status-responsive gene expression." BMC Systems
Biology 10, no. 1 (12, 2016): 1-13.
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