%0 PDF %T The game theory of Candida albicans colonization dynamics reveals host status-responsive gene expression. %A Tyc, Katarzyna M.; Herwald, Sanna E.; Hogan, Jennifer A.; Pierce, Jessica V.; Klipp, Edda.; Kumamoto, Carol A. %D 2016-08-16T18:22:34.267Z %8 2016-08-16 %R http://localhost/files/3197xz63s %X Background: The fungal pathogen Candida albicans colonizes the gastrointestinal (GI) tract of mammalian hosts as a benign commensal. However, in an immunocompromised host, the fungus is capable of causing life-threatening infection. We previously showed that the major transcription factor Efg1p is differentially expressed in GI-colonizing C. albicans cells dependent on the host immune status. To understand the mechanisms that underlie this host-dependent differential gene expression, we utilized mathematical modeling to dissect host-pathogen interactions. Specifically, we used principles of evolutionary game theory to study the mechanism that governs dynamics of EFG1 expression during C. albicans colonization.; Keywords: Candida albicans, Colonization, Fungal pathogen, Microbiota, Efg1p, Evolutionary game theory, Mathematical modeling.; Springer Open. %[ 2018-10-11 %9 Text %~ Tufts Digital Library %W Institution