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Previous research has suggested there may be two independent sets of covarying degenerative brain changes contributing to the development of Alzheimer’s disease (AD): ‘age-and-vascular’ associated damage and classical ‘neurodegenerative’ changes. This study investigated the relationship between both sets of brain changes and various domains of cognition over a two year period in individuals with ... read moremild cognitive impairment, a necessary intermediate stage before Alzheimer's disease. Our results confirm the relevance of studying white matter changes in mild cognitive impairment as this pathology may suggest a secondary, concurrent pathway to AD development.read less
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