Partial Synthesis of the Tetrasaccharide Fragment of ArugomycinTrotta, Adam H.
Arugomycin is a biologically active natural product, showing both antibacterial and antitumor activities. It intercalates in DNA, binding to both the major and minor grooves. The two oligosaccharide chains play important roles in stabilizing the arugomycin-DNA complex. In recent years the Bennett lab has pioneered a strategy for cyclopropenium cation promoted dehydrative glycosylatio... read more
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