A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake.

Kritzer, Joshua A.
Quartararo, Justin.
Eshelman, Matthew R.
Peraro, Leila.
Yu, Hongtao.
Baleja, James D.
Lin, Yu-Shan.
2014.

While peptides are promising as probes and therapeutics, targeting intracellular proteins will require greater understanding of highly structured, cell-internalized scaffolds. We recently reported BC1, an 11-residue bicyclic peptide that inhibits the Src homology 2 (SH2) domain of growth factor receptor-bound protein 2 (Grb2) In this work, we describe the unique structural and cell uptake properti... read more

Subjects
Peptides.
Proteins.
Tufts University. Department of Chemistry.
Permanent URL
http://hdl.handle.net/10427/013725
Original publication
Quartararo, J., Eshelman, M., Peraro, L., Yu, H., Baleja, J.D., Lin, Y., Kritzer, J.A. A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake. Bioorg. Med. Chem. 2014 22(22), 6387-6391. doi:10.1038/nchembio.407.
ID: tufts:23292
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