A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake.Kritzer, Joshua A.
Eshelman, Matthew R.
Baleja, James D.
While peptides are promising as probes and therapeutics, targeting intracellular proteins will require greater understanding of highly structured, cell-internalized scaffolds. We recently reported BC1, an 11-residue bicyclic peptide that inhibits the Src homology 2 (SH2) domain of growth factor receptor-bound protein 2 (Grb2) In this work, we describe the unique structural and cell uptake properti... read more
- Tufts University. Department of Chemistry.
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- Original publication
- Quartararo, J., Eshelman, M., Peraro, L., Yu, H., Baleja, J.D., Lin, Y., Kritzer, J.A. A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake. Bioorg. Med. Chem. 2014 22(22), 6387-6391. doi:10.1038/nchembio.407.