Co-delivering of RNase A-NBC and Glucose Oxidase for Targeted Cancer Therapy.

Xu, Jingqiong.

Abstract: Previously, the successful delivery of RNase A modified with a reactive oxygen species (ROS) responsive modification (RNase A-NBC) to tumor cells, showed cancer specific induced cytotoxicity. Here, we propose a novel combination formulation comprised of Glucose Oxidase (GOx), a ROS-generating protein, and RNase A-NBC delivered using lipidoid nanoparticles. The feasibility and optimizatio... read more

Tufts University. Department of Biomedical Engineering.
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ID: tufts:21565
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