| Description |
-
Abstract: A 46 year old male patient with metastatic prostate cancer
developed Stevens-Johnson syndrome (SJS), initially in three well-demarcated areas on
his scalp, chest and back, corresponding to ports of radiation therapy while on
phenytoin. The rash spread from these locations and became more generalized and
associated with pain and ... read moresloughing in the mucous lining of the mouth. There is a
documented association between phenytoin administration with concurrent cranial
radiation therapy and development of SJS. Erythema multiforme (EM) associated with
phenytoin and cranial radiation therapy (EMPACT) is the term that describes this
reaction. However, this term may not cover the full spectrum of the disease since it
describes EM associated with phenytoin and only cranial radiation therapy. This case
report presents evidence that SJS may be induced by radiation to other parts of the
body in addition to the cranium while phenytoin is administered concomitantly. With
increasing evidence that phenytoin and levetiracetam are equally efficacious for
seizure treatment and prophylaxis, and since there is no link identified so far of an
association between levetiracetam and SJS, we believe that levetiracetam is a better
option for patients who need anticonvulsant medication(s) while undergoing radiation
therapy, especially cranial irradiation.
Keywords: Anti-Epileptic Drugs, Stevens-Johnson Syndrome, Erythema
Multiforme associated with Phenytoin And Cranial Radiation Therapy, Erythema
Multiforme, Toxic Epidermal Necrolysis.
Springer Open.read less
|
|---|
This object is in collection
| Citation |
- Kandil, Abdullah, Tomas Dvorak, John Mignano, Julian K. Wu,
and Jay-Jiguang Zhu. "Multifocal Stevens-Johnson syndrome after concurrent phenytoin
and cranial and thoracic radiation treatment, a case report." Radiation Oncology 5,
no. 1 (12, 2010): 1-5.
|
|---|
