Regulation of the Transcriptional Repressor Slug in Breast Tumor and DNA Repair

Zhou, Wenhui.


  • Overabundance of Slug protein is common in human cancer and represents an important determinant underlying the aggressiveness of basal-like breast cancer (BLBC). Despite its importance, this transcription factor is rarely mutated in BLBC, and the mechanism by which it becomes deregulated in cancer remains unknown. Here we report that Slug undergoes acetylation-dependent protein degradation and ... read more
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