Predicting the in vivo pulmonary toxicity induced by acute exposure to poorly soluble nanomaterials by using advanced in vitro methods.

Loret, Thomas.

Rogerieux, Françoise.

Trouiller, Bénédicte.

Braun, Anne.

Egles, Christophe.

Lacroix, Ghislaine.


  • Background: Animal models remain at that time a reference tool to predict potential pulmonary adverse effects of nanomaterials in humans. However, in a context of reduction of the number of animals used in experimentation, there is a need for reliable alternatives. In vitro models using lung cells represent relevant alternatives to assess potential nanomaterial acute toxicity by inhalation, ... read more
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