Inhibitory Effects of Sulfonylureas and Non-Steroidal Anti-Inflammatory Drugs on In-Vitro Metabolism of Canagliflozin in Human Liver Microsomes

Algeelani, Sara.

2017

Description
  • Abstract: Canagliflozin, a sodium-glucose transport protein 2 (SGLT2) inhibitor, is a novel drug used to treat type 2 diabetes mellitus (T2DM). A phase II glucuronide conjugation reaction is the primary elimination pathway of canagliflozin. Uridine diphosphate glucuronosyltransferases (UGTs) are the responsible enzymes for the glucuronidation reactions that occur in phase II metabolism. The gl... read more
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