Convergent Synthesis Approach for Stereospecific Preparation of Fluorinated Carbohydrates in Exploration of Cell Surface Receptor-Ligand Interactions.

Akçay, Gizem.


  • Abstract: Metastasis, where cancer cells lethally spread throughout the body is facilitated by specific carbohydrate-protein interactions. Cancer cells that detach from the primary tumor and penetrate blood vessels can survive and move along the blood stream by adhering to vascular surfaces. This cellular adhesion is mediated by a tetrasaccharide epitope sialyl Lewis X, that is overexpressed on mo... read more
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