Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorphism: a systematic review of studies in breast, lung, colorectal, ovarian, and endometrial cancer.

Dahabreh, Issa.

2011

Description
  • Abstract: Background: Genetic association studies in oncology often use tumor tissue as the source of genotyping material for cancer patients. Because tumors exhibit multiple somatic genetic aberrations, tumor-derived genetic material may not accurately represent the individual's constitutional genotype. Loss-of-heterozygosity (LOH) that preferentially affects one variant allele at a locus ma... read more
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