On the role of translesion synthesis polymerase Rev1 in homologous recombination and DNA damage tolerance

Khodaverdian, Varandt.


  • Abstract: DNA is frequently damaged by exogenous and endogenous agents. DNA lesions are particularly dangerous during DNA replication as replicative polymerases associated with the replication fork cannot efficiently utilize modified bases as templates. As a result, the replication fork can stall as it encounters DNA lesions, and ultimately collapse, if the stall persist. Collapsed forks result ... read more
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