Ultrasensitive single-genome sequencing: accurate, targeted, next generation sequencing of HIV-1 RNA.

Boltz, Valerie F.

Rausch, Jason.

Shao, Wei.

Hattori, Junko.

Luke, Brian.

Maldarelli, Frank.

Mellors, John W.

Kearney, Mary F.

Coffin, John M.

2016

Description
  • Background: Although next generation sequencing (NGS) offers the potential for studying virus populations in unprecedented depth, PCR error, amplification bias and recombination during library construction have limited its use to population sequencing and measurements of unlinked allele frequencies. Here we report a method, termed ultrase... read more
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  • Boltz, Valerie, Jason Rausch, Wei Shao, Junko Hattori, Brian Luke, Frank Maldarelli, John W. Mellors, Mary F. Kearney, and John M. Coffin. "Ultrasensitive single-genome sequencing: accurate, targeted, next generation sequencing of HIV-1 RNA." Retrovirology 13, no. 1 (12, 2016): 1-17.
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