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Abstract: Posttraumatic Stress Disorder (PTSD) is a potentially debilitating mental health condition that can occur after exposure to trauma. Previous research has shown heightened psychophysiological responses and blunted anterior cingulate cortex (ACC) activation in PTSD during recollection of traumatic events. However, fewer studies have examined responses to the recollection of other stressful ... read morebut trauma-unrelated life events in PTSD. The origin of these biological abnormalities in PTSD, whether they are acquired signs of PTSD or familial vulnerability factors, is unknown. In the current case-control twin study, twenty-six male, monozygotic twin pairs (12 PTSD; 14 Non-PTSD) discordant for trauma exposure completed script-driven imagery (SDI) using stressful, trauma-unrelated autobiographical narratives. Skin conductance, brain activation, and subjective responses to the recollection and imagery of Stressful versus Neutral life events were measured. Results indicate that lack of skin conductance response modulation across conditions and reduced rostral ACC activation may be acquired characteristics of PTSD.
Thesis (M.S.)--Tufts University, 2015.
Submitted to the Dept. of Psychology.
Advisor: Lisa Shin.
Committee: Heather Urry, and Scott Orr.
Keywords: Clinical psychology, Physiological psychology, and Psychobiology.read less
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