Genetic deletion of calpain-1 and pharmacological inhibition of calpain activity improve red blood cell morphology and reduce sickling in humanized mouse model of sickle cell disease

Butabayeva, Aliya.


  • Sickle cell disease (SCD) is a genetic hematological disorder caused by inheriting two copies of mutated hemoglobin S gene (HbS) located in codon 6 of globin gene causing the insertion of valine in place of glutamic acid. The mutated hemoglobin undergoes increased polymerization in deoxygenated state, and changes erythrocyte properties generating sickle shape. It has significantly short life ... read more
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