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Abstract: This thesis
describes functions of the cell surface adhesion molecule Nectin-like molecule 5
(Necl-5) and its role in the pathogenesis of the deadly brain tumor glioblastoma (GBM).
This thesis presents data showing that Necl-5 has two functions that have not been
previously described. First, it promotes MMP-2 production, which is important for the
invasive phenotype of GBM, and that... read more