Description |
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Abstract: Of all of the
infectious diseases known in modern times {e.g. Tuberculosis, Cholera, Ebola, Severe
Acute Respiratory Syndrome (SARS), Meningitis, Middle Eastern Respiratory Syndrome
(MERS)} none has had greater impact on global health as malaria. About 1.2 billion
people live in areas endemic with this disease with nearly half a million fatalities
every year. Chemotherapeutic ... read moreapplications since the 1820s have been formulated as
preventative measures and for the treatment of malaria infections. Unfortunately, since
its inception, multiple issues with patient compliance and drug formulations have led to
increasing resistance from the malaria causing parasite Plasmodium. This project focuses
on using oral film technology (OFT) with the novel application of dissolvable silk films
for drug delivery to the oral mucosa. The antimalarial prophylactic, mefloquine
hydrochloride was studied and found to be suitable for this application. This approach
has potential to be instrumental as a type of application for other antimalarial
therapeutics that are unable to be orally administered and also to increase patient
compliance in areas endemic with the disease.
Thesis
(M.S.)--Tufts University, 2016.
Submitted to the
Dept. of Biomedical Engineering.
Advisor: David
Kaplan.
Committee: Qiaobing Xu, and Hyunmin
Yi.
Keyword: Biomedical
engineering.read less
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