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Background: Obesity is associated with low-grade inflammation and
impaired immune response. Caloric restriction (CR) has been shown to inhibit
inflammatory response and enhance cell-mediated immune function. Curcumin, the
bioactive phenolic component of turmeric spice, is proposed to have anti-obesity and
anti-inflammation properties while ... read morepiperine, another bioactive phenolic compound
present in pepper spice, can enhance the bioavailability and efficacy of curcumin.
This study sought to determine if curcumin could potentiate CR's beneficial effect on
immune and inflammatory responses in obesity developed in mice by feeding high-fat
Keywords: Obesity, Caloric restriction, Inflammation, T cells, Curcumin,
Springer Open.read less
- Wang, Junpeng, Sally M. Vanegas, Xiaogang Du, Timothy Noble,
Jean-Marc A. Zingg, Mohsen Meydani, Simin Nikbin Meydani, and Dayong Wu. "Caloric
restriction favorably impacts metabolic and immune/inflammatory profiles in obese
mice but curcumin/piperine consumption adds no further benefit." Nutrition &
Metabolism 10, no. 1 (12, 2013): 1-10.