The Role and Regulation of Sox9 in the Human Hair Follicle and Basal Cell Carcinoma.

Reeves, Andrew.


  • Abstract: Constitutively activating mutations in the Sonic Hedgehog pathway are the drivers of basal cell carcinoma (BCC). However, while these mutations may be the initial driver of tumor formation it has more recently been established that without Wnt/β-catenin signaling the Shh mutations cannot lead to tumor formation. The transcription factor Sox9 is a target of both Shh and Wnt signaling and ... read more
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