Neuroimaging predictors of treatment response in anxiety disorders.
Shin, Lisa M.
Davis, F Caroline.
VanElzakker, Michael B.
Dahlgren, Mary K.
Dubois, Stacey J.
Abstract: Although several psychological and pharmacological treatment
options are available for anxiety disorders, not all patients respond well to each
option. Furthermore, given the relatively long duration of adequate treatment trials,
finding a good treatment fit can take many months or longer. Thus, both clinicians
and patients woul... read mored benefit from the identification of objective pre-treatment
measures that predict which patients will best respond to a given treatment. Recent
studies have begun to use biological measures to help predict symptomatic change
after treatment in anxiety disorders. In this review, we summarize studies that have
used structural and functional neuroimaging measures to predict treatment response in
obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD),
generalized anxiety disorder (GAD), and social anxiety disorder (SAD). We note the
limitations of the current studies and offer suggestions for future research.
Although the literature is currently small, we conclude that pre-treatment
neuroimaging measures do appear to predict treatment response in anxiety disorders,
and future research will be needed to determine the relative predictive power of
neuroimaging measures as compared to clinical and demographic
Keywords: Social anxiety disorder, Obsessive-compulsive disorder, Posttraumatic stress disorder, Generalized anxiety disorder, Amygdala, Medial prefrontal cortex, Anterior cingulate cortex, Orbitofrontal cortex, fMRI, PET.
Springer Open.read less
- Shin, Lisa, F. Caroline Davis, Michael B. VanElzakker, Mary K. Dahlgren, and Stacey J. Dubois. "Neuroimaging predictors of treatment response in anxiety disorders." Biology of Mood & Anxiety Disorders 3, no. 1 (12, 2013): 1-11.