The Interaction of DNA Double-Strand Break Repair and CAG/CTG Trinucleotide Repeat Instability in Drosophila melanogaster.

Blackmer, Jane E.


  • Trinucleotide repeats are the underlying molecular cause of many neurodegenerative disorders. A common feature of these repeats is their length dependence. When the repeat number is below a certain threshold, there are no symptoms of disease. Once expanded past a certain threshold, however, these repeats cause pathology on the DNA, RNA, and protein level. Repeats can expand in both somatic tissue ... read more
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