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Background: Bone marrow-derived mesenchymal stromal cells (BMSCs) are a
cell population of intense exploration for therapeutic use in inflammatory diseases.
Secreted factors released by BMSCs are responsible for the resolution of inflammation
in several pre-clinical models. New studies have uncovered that adipose tissue also
serves as a ... read morereservoir of multipotent, non-hematopoietic stem cells, termed
adipose-derived stromal/stem cells (ASCs), with many common characteristics to BMSCs.
We hypothesized that ASC and BMSC secreted factors would lead to a comparable benefit
in the context of generalized inflammation.
Keywords: Soluble receptors, Mesenchymal stem cells, Adipose stem cells,
Endotoxic shock, Tissue necrosis factor alpha (TNF-α), Vascular endothelial growth
Springer Open.read less
- Elman, Jessica, Matthew Li, Fangjing Wang, Jeffrey M. Gimble,
and Biju Parekkadan. "A comparison of adipose and bone marrow-derived mesenchymal
stromal cell secreted factors in the treatment of systemic inflammation." Journal of
Inflammation 11, no. 1 (12, 2014): 1-8.