Solution structure of a designed cyclic peptide ligand for nickel and copper ions.

Kritzer, Joshua A.

Eshelman, Matthew R.

Aldous, Amanda.

Neupane, Kosh P.


  • Nuclear magnetic resonance (NMR) spectroscopy was used to study a cyclic peptide derived from the amino-terminal copper-and-nickel-binding (ATCUN) motif. The three-dimensional structure of the unliganded peptide in aqueous solution was solved by simulated annealing using distance constraints derived from Nuclear Overhauser Effects. A structural model for the Ni(II)-bound complex was also produced ... read more
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  • Eshelman, M.R., Aldous, A.R., Neupane, K.P., and Kritzer, J.A. Solution Structure of a Designed Cyclic Peptide Ligand for Nickel and Copper Ions. Tetrahedron 2014 70(42), 7651-7654. doi:10.1016/j.tet.2014.07.083.
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