Background: Astrocytomas are the most common type of primary central
nervous system tumors. They are frequently associated with genetic mutations that
deregulate cell cycle and render these tumors resistant to apoptosis. STAT3, signal
transducer and activator of transcription 3, participates in several human cancers by
inducing cell ... read moreproliferation and inhibiting apoptosis and is frequently activated in
astrocytomas.
Konnikova, Liza, Maciej Kotecki, Mathew M. Kruger, and Brent
H. Cochran. "Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma
cells." BMC Cancer 3, no. 1 (12, 2003): 1-9.