Investigating the role of autophagy in TLR7-mediated SLE pathogenesis.

Weindel, Catherine.

2015

Description
  • Abstract: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease, defined by loss of B cell self-tolerance that results in production of anti-nuclear antibodies and chronic inflammation. While the initiating events in lupus development are not well defined, overexpression of the RNA-recognizing toll-like receptor (TLR)7 has been linked to SLE in humans and mice. We postulated tha... read more
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