Rapid selection of cyclic peptides that reduce α-synuclein toxicity in yeast and animal models.

Kritzer, Joshua A.

Hamamichi, Shusei.

McCaffery, J. Michael.

Santagata, Sandro.

Naumann, Todd A.

Caldwell, Kim A.

Caldwell, Guy A.

Lindquist, Susan.


  • Phage display has demonstrated the utility of cyclic peptides as general protein ligands but cannot access proteins inside eukaryotic cells. Expanding a new chemical genetics tool, we describe the first expressed library of head-to-tail cyclic peptides in yeast (Saccharomyces cerevisiae) We applied the library to selections in a yeast model of α-synuclein toxicity that recapitulates much of the ... read more
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  • Kritzer, J. A.; Hamamichi, S.; McCaffery, J. M.; Santagata, S.; Naumann, T. A.; Caldwell, K. A.; Caldwell, G. A.; Lindquist, S. Rapid Selection of Cyclic Peptides That Reduce Α-Synuclein Toxicity in Yeast and Animal Models. Nature Chemical Biology 2009, 5 (9), 655-663 DOI: 10.1038/nchembio.193.
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