Label-free, multi-parametric assessments of cell metabolism and matrix remodeling within human and early-stage murine osteoarthritic articular cartilage.

Liu, Zhiyi.

Hui Mingalone, Carrie K.

Gnanatheepam, Einstein.

Hollander, Judith M.

Zhang, Yang.

Meng, Jia.

Zeng, Li.

Georgakoudi, Irene.

2023

Description
  • Osteoarthritis (OA) is characterized by the progressive deterioration of articular cartilage, involving complicated cell-matrix interactions. Systematic investigations of dynamic cellular and matrix changes during OA progression are lacking. In this study, we use label-free two- photon excited fluorescence (TPEF) and second harmonic generation (SHG) imaging to assess cellular and extracellular ... read more
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  • Liu, Z., Hui Mingalone, C.K., Gnanatheepam, E. et al. Label-free, multi-parametric assessments of cell metabolism and matrix remodeling within human and early-stage murine osteoarthritic articular cartilage. Commun Biol 6, 405 (2023). https://doi.org/10.1038/s42003-023-04738-w