A comparative risk assessment of the impact of dietary factors on mortality from cardiovascular disease and diabetes in countries in Latin America and the Caribbean
Abstract: Over recent
decades, the burden of cardiovascular disease and diabetes has increased in countries in
Latin America and Caribbean (LAC). However, there are currently no comprehensive
quantitative estimates of how changes in diet have contributed to this shifting burden.
This study aims to quantify the extent of cardiometabolic disease (CMD) mortality
attributable to 11 dietary factor... read mores in 32 countries in LAC between 1990 and 2010. The
national dietary exposure distributions were obtained from the NutriCoDE database. The
effects of each dietary factor on disease-specific mortality were obtained from a
variety of observational studies and clinical trials. The number of cause-specific
deaths was obtained from the 2010 Global Burden of disease mortality database. We
combined these databases to compute cause-specific population-attributable fractions for
11 dietary factors, which were multiplied by cause-specific mortality to obtain the
estimates of individual dietary factors-attributable deaths. Analyses were done by
country/age/sex/time; uncertainties of all input data were propagated into final
estimates. In 2010, low intakes of nuts and seeds (12.4%), fruits (11.4%), and seafood
ω-3 fatty acids (9.6%) were the largest contributors to CMD deaths in the region.
Among harmful dietary factors, high intake of sodium (6%) was the leading risk factor
for CMD mortality. No single country consistently showed a healthier consumption
behavior in any of the dietary factors. Approximately 48% of all CMD occurred
prematurely (below the age of 70 years). The countries of Guyana and Trinidad &
Tobago experienced the highest rates of CMD mortality while the lowest rates were
observed in Peru and the Bahamas. Important similarities and differences were observed
in the impact of various dietary factors on CMD mortality across these countries. This
data can be used to inform future health policy and program
Thesis (M.S.)--Tufts University, 2017.
Submitted to the Dept. of Clinical & Translational Science.
Advisor: Raveendhara Bannuru.
Committee: Gitanjali Singh, and Robin Ruthazer.
Keywords: Epidemiology, and Nutrition.read less