Human cytochromes mediating in vitro metabolism of lurasidone

Wei, Zixuan.


  • The objective of this study was to develop an in vitro metabolic profile for lurasidone to determine pharmacokinetic parameters Vmax and Km, and to model potential drug-drug interactions. Lurasidone was first approved for clinical use in the United States in 2010 as a second-generation antipsychotic drug. Clinical studies have shown it has been a successful agent when used to treat patients ... read more
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