Next-generation DNA sequencing technologies and the study of trinucleotide repeat instability

McGinty, Ryan.


  • Abstract: Microsatellite repeats are the source of multiple hereditary diseases in humans. Certain repetitive sequences form unusual DNA structures that differ from standard B-form DNA. As the length of a repeat increases, structures form more frequently and stably. Secondary structures can interfere with numerous cellular processes, leading to expansions and contractions of the repetitive tract, ... read more
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