Bioinspired 3D Cocultures of Human Skeletal Myoblasts and Motoneuron-like Cells to Investigate Neuromuscular Function In Vitro

Dixon, Thomas.


  • Abstract: The physical connection in the developing embryo between ventral horn motoneurons and skeletal muscle myoblasts is responsible for the creation of neuromuscular junctions (NMJs), which allow electrical signals from the spinal cord to be translated to mechanical work in contractile skeletal muscle. Pathology at the NMJ contributes to the spectrum of neuromuscular, motoneuron, and dyst... read more
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