Peptide Bicycles that Inhibit the Grb2 SH2 Domain.

Kritzer, Joshua A.

Quartararo, Justin.

Wu, Pianpian.


  • Developing short peptides into useful probes and therapeutic leads remains a difficult challenge. Structural rigidification is a proven method for improving the properties of short peptides. In this work, we report a strategy for stabilizing peptide macrocycles by introducing side-chain-to-side-chain staples to produce peptide bicycles with higher affinity, selectivity, and resistance to degradation. ... read more
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  • Quartararo, J. S., Wu, P. and Kritzer, J. A. (2012), Peptide Bicycles that Inhibit the Grb2 SH2 Domain. ChemBioChem, 13: 1490-1496. doi:10.1002/cbic.201200175.
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