Targeting the tumor microenvironment with protein-small molecule hybrids

Kehoe, Haixing.


  • Abstract: In cancer, changes in enzyme expression levels and activity levels lead to a complex, altered microenvironment that promotes unregulated cell growth, angiogenesis, and metastasis. The biology of the tumor microenvironment, including the roles of the proteases and peptidases involved, remains poorly characterized. Evaluating the functions of these enzymes is challenging due to the absence... read more
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