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Background: The tumor microenvironment has complex effects in cancer
pathophysiology that are not fully understood. Most cancer therapies are directed
against malignant cells specifically, leaving pro-malignant signals from the
microenvironment unaddressed. Defining specific mechanisms by which the tumor
microenvironment contributes to ... read morebreast cancer metastasis may lead to new therapeutic
approaches against advanced breast cancer.
Keywords: Tiam1, Osteopontin, Breast cancer, Cancer-associated
fibroblast, Agelastatin, Metastasis.
Springer Open.read less
- Xu, Kun, Xuejun Tian, Sun Y. Oh, Mohammad Movassaghi, Stephen
P. Naber, Charlotte Kuperwasser, and Rachel J. Buchsbaum. "The fibroblast
Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis." Breast
Cancer Research 18, no. 1 (12, 2016): 1-15.