T cell adhesion to TCR and Beta-1 integrin ligands is differentially controlled by the SKAP55 N-terminus.

Ophir, Michael.


  • Abstract: Productive immune responses require optimal T cell activation. T cell activation is dependent on TCR-initiated signaling events that occur within compartmentalized signaling complexes known as SLP-76 microclusters. SLP-76 microclusters are sites of active tyrosine phosphorylation and enzymatic activity at the immune synapse. Furthermore, SLP-76 microclusters recruit a variety of adaptor ... read more
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