An integrated multidisciplinary model describing initiation of cancer and the Warburg hypothesis.

Rietman, Edward A.

Friesen, Douglas E.

Hahnfeldt, Philip.

Gatenby, Robert.

Hlatky, Lynn.

Tuszynski, Jack A.

2013

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  • Background: In this paper we propose a chemical physics mechanism for the initiation of the glycolytic switch commonly known as the Warburg hypothesis, whereby glycolytic activity terminating in lactate continues even in well-oxygenated cells. We show that this may result in cancer via mitotic failure, recasting the current conception of ... read more
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  • Rietman, Edward, Douglas E. Friesen, Philip Hahnfeldt, Robert Gatenby, Lynn Hlatky, and Jack A. Tuszynski. "An integrated multidisciplinary model describing initiation of cancer and the Warburg hypothesis." Theoretical Biology and Medical Modelling 10, no. 1 (12, 2013): 1-19.
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