| Description |
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Background: In this paper we propose a chemical physics mechanism for
the initiation of the glycolytic switch commonly known as the Warburg hypothesis,
whereby glycolytic activity terminating in lactate continues even in well-oxygenated
cells. We show that this may result in cancer via mitotic failure, recasting the
current conception of ... read morethe Warburg effect as a metabolic dysregulation consequent to
cancer, to a biophysical defect that may contribute to cancer
initiation.
Keywords: Warburg effect, Rayleigh-Benard convection, Aneuploidy,
Glycolysis, Genomic instability.
Springer Open.read less
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| Citation |
- Rietman, Edward, Douglas E. Friesen, Philip Hahnfeldt, Robert
Gatenby, Lynn Hlatky, and Jack A. Tuszynski. "An integrated multidisciplinary model
describing initiation of cancer and the Warburg hypothesis." Theoretical Biology and
Medical Modelling 10, no. 1 (12, 2013): 1-19.
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