Metal-binding and redox properties of substituted linear and cyclic ATCUN motifs.

Kritzer, Joshua A.

Aldous, Amanda.

Neupane, Kosh P.


  • The amino-terminal copper and nickel binding (ATCUN) motif is a short peptide sequence found in human serum albumin and other proteins. Synthetic ATCUN-metal complexes have been used to oxidatively cleave proteins and DNA, cross-link proteins, and damage cancer cells. The ATCUN motif consists of a tripeptide that coordinates Cu(II) and Ni(II) ions in a square planar geometry, anchored by chelation ... read more
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