The role of deficits in KCC2-mediated ion transport in the development and severity of temporal lobe epilepsy

Kelley, Matt.


  • Abstract: Temporal lobe epilepsy is the most common form of human epilepsy, believed to arise in part from compromised GABAergic inhibition. GABAA receptors permit an inward chloride flux to mediate membrane hyperpolarization and restrict neuronal firing. In most adult brain neurons, the activity of the membrane expressed type 2 K+-Cl- cotransporter (KCC2) maintains the low intracellular ... read more
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