%0 PDF %T Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology. %A Pilatova, Katerina.; Greplova, Kristina.; Demlova, Regina.; Bencsikova, Beatrix.; Klement, Giannoula Lakka.; Zdrazilova-Dubska, Lenka. %D 2016-08-16T18:23:46.204Z %8 2016-08-16 %R http://localhost/files/vd66wb48v %X Abstract: With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.; Keywords: Platelet, PF-4, CTAP-III, Cancer, Angiogenesis, IL-8, Inflammation.; Springer Open. %[ 2018-10-11 %9 Text %~ Tufts Digital Library %W Institution