| Description |
-
Background: Consistent asymmetry of the left-right (LR) axis is a
crucial aspect of vertebrate embryogenesis. Asymmetric gene expression of the TGFβ
superfamily member Nodal related 1 (Nr1) in the left lateral mesoderm plate is a
highly conserved step regulating the situs of the heart and viscera. In Xenopus,
movement of maternal serotonin ... read more(5HT) through gap-junctional paths at cleavage stages
dictates asymmetry upstream of Nr1. However, the mechanisms linking earlier
biophysical asymmetries with this transcriptional control point are not
known.
Keywords: Xenopus, left-right asymmetry, laterality, Nodal,
HDAC.
Springer Open.read less
|
|---|
This object is in collection
| Citation |
- Carneiro, Katia, Claudia Donnet, Tomas Rejtar, Barry L.
Karger, Gustavo A. Barisone, Elva Díaz, Sandhya Kortagere, Joan M. Lemire, and
Michael Levin. "Histone deacetylase activity is necessary for left-right patterning
during vertebrate development." BMC Developmental Biology 11, no. 1 (12, 2011):
1-19.
|
|---|
