The Integrated Role of Wnt Signaling, mTOR Signaling and Glutamate Metabolism as a Possible Drug Target for Epilepsy in HBP1-/- Mice

Alkhelb, Dalal.


  • Abstract: We have shown that Wnt signaling is activated in the hippocampus 5 days following status epilepticus (SE), and that Wnt signaling activates a Warburg-like metabolic program. We hypothesized that Wnt-signaling induced Warburg metabolism contributes to the ratio of GABA to glutamate, which is a critical factor in the progression to chronic seizures and whose syntheses derive from TCA ... read more
This object is in collection Creator department Thesis Type Genre Permanent URL
Component ID:
To Cite:
TARC Citation Guide    EndNote