| Description |
-
Introduction: This study was designed to determine if and how a
non-toxic, naturally occurring bioflavonoid, galangin, affects proliferation of human
mammary tumor cells. Our previous studies demonstrated that, in other cell types,
galangin is a potent inhibitor of the aryl hydrocarbon receptor (AhR), an
environmental carcinogen-responsive ... read moretranscription factor implicated in mammary tumor
initiation and growth control. Because some current breast cancer therapeutics are
ineffective in estrogen receptor (ER) negative tumors and since the AhR may be
involved in breast cancer proliferation, the effects of galangin on the proliferation
of an ER-, AhRhigh line, Hs578T, were studied.
Keywords: α-naphthoflavone, aryl hydrocarbon receptor, aryl hydrocarbon
receptor repressor, aryl hydrocarbon receptor nuclear translocator, Dulbecco's
modified Eagle's medium, estrogen receptor, fetal calf serum, indole 3-carbinol,
polycyclic aromatic hydrocarbon, Per/ARNT/Sim, phosphate-buffered saline, propidium
iodide, 2,3,7,8-tetrachlorodibenzo-p-dioxi.
Springer Open.read less
|
|---|
This object is in collection
| Citation |
- Murray, Tessa, Xinhai Yang, and David H. Sherr. "Growth of a
human mammary tumor cell line is blocked by galangin, a naturally occurring
bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A." Breast
Cancer Research 8, no. 6 (4, 2006): 1-12.
|
|---|
